Pristiq

desvenlafaxine
Chemical Name: desvenlafaxine (as succinate)
Drug Type: SSNRI antidepressants

You should not use this medicine if you are being treated with linezolid or methylene blue injection.

Do not use desvenlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Do not stop using desvenlafaxine without first talking to your doctor.

Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRIs) antidepressant. Desvenlafaxine affects chemicals in the brain that may be unbalanced in people with depression.

Desvenlafaxine is used to treat major depressive disorder.

Desvenlafaxine may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to desvenlafaxine or venlafaxine (Effexor).

Do not use desvenlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur.

Some medicines can interact with desvenlafaxine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

To make sure desvenlafaxine is safe for you, tell your doctor if you have ever had:

  • heart disease, high blood pressure, high cholesterol, or a stroke;
  • bipolar disorder (manic depression);
  • depression, suicidal thoughts;
  • liver or kidney disease;
  • glaucoma;
  • seizures or epilepsy;
  • a bleeding or blood clotting disorder; or
  • low levels of sodium in your blood.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Desvenlafaxine may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Desvenlafaxine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Desvenlafaxine is not approved for use by anyone younger than 18 years old.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take desvenlafaxine with or without food. Take the medicine at the same time each day.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Your blood pressure will need to be checked often.

It may take several weeks before your symptoms improve. Keep using the medication as directed. Do not stop using desvenlafaxine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medicine suddenly.

Store at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid drinking alcohol. It can increase certain side effects of desvenlafaxine.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with desvenlafaxine may cause you to bruise or bleed easily.

Desvenlafaxine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Get emergency medical help if you have signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • seizure (convulsions);
  • easy bruising or bleeding (nosebleeds, bleeding gums), blood in your urine or stools, coughing up blood;
  • blurred vision, eye pain or swelling, or seeing halos around lights;
  • cough, chest tightness, trouble breathing; or
  • low levels of sodium in the body--headache, confusion, severe weakness, loss of coordination, feeling unsteady, hallucinations.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea

Common side effects may include:

  • dizziness, drowsiness, anxiety;
  • increased sweating;
  • nausea, decreased appetite, constipation;
  • sleep problems (insomnia); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Taking desvenlafaxine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with desvenlafaxine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • any other antidepressant;
  • sibutramine;
  • St. John's wort;
  • tramadol;
  • tryptophan (sometimes called L-tryptophan);
  • lithium, or other medicine to treat mood disorders, thought disorders, or mental illness; or
  • migraine headache medicine--sumatriptan, zolmitriptan, and others.

This list is not complete and many other drugs can interact with desvenlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Your pharmacist can provide more information about desvenlafaxine.